|
KMID : 0939920100420020118
|
|
대한암학회지
2010 Volume.42 No. 2 p.118 ~ p.120
|
|
|
A Case of 5-Fluorouracil Induced Encephalopathy
|
|
Kwon Kyung-A
Kwon Hyuk-Chan
Kim Min-Chan
Kim Sung-Hyun
Oh Sung-Yong
Lee Suee
Kim Hyo-Jin
|
|
|
Abstract
|
|
|
|
Patients with reduced dihydropyrimidine dehydrogenase (DPD) activity are at risk for experiencing serious adverse effects following 5-fluorouracil (5-FU) based chemotherapy. Neurotoxicity is considered an extremely rare side effect of 5-FU. We report here on an unusual case of 5-FU induced encephalopathy. A 38-year-old woman with advanced gastric carcinoma was treated with adjuvant chemotherapy that consisted of infused 5-FU (1,000 mg/m2) for 5 days and cisplatin (60 mg/m2) on day 1 following total gastrectomy. Nineteen days after starting chemotherapy, the patient displayed a sudden onset of slurred speech, confusion, cognitive disturbances and paranoia. A magnetic resonance image (MRI) of the brain showed no structural abnormalities, and the other laboratory tests provided no explanations for her symptoms, other than a slightly elevated ammonia level. The patient was treated with a lactulose retention enema and thiamine infusion, the 5-FU was halted and her symptoms then recovered after 7 days.
|
|
|
KEYWORD
|
|
|
5-FU, Neurotoxicity, Encephalopathy
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
    
|